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RIPK3-IN-1

Cat. No. M13405
RIPK3-IN-1  Structure
Size Price Availability Quantity
10mg USD 670  USD670 In stock
25mg USD 1320  USD1320 In stock
50mg USD 2100  USD2100 In stock
100mg USD 3000  USD3000 In stock
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Quality Control & Documentation
Biological Activity

RIPK3-IN-1 is a RIPK3 TYPE II DFG-out inhibitor with IC50 of 9.1 nM. RIPK3-IN-1 inhibited ABL, BRAF/V599E, MAP4K3 and SRC with IC50 values of 0.37, 0.15, 0.012 and 0.075 μM, respectively.

Chemical Information
Molecular Weight 512.53
Formula C29H25FN4O4
CAS Number 2361139-70-8
Solubility (25°C) DMSO : 5 mg/mL
Storage -20°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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  Catalog
Abmole Inhibitor Catalog




Keywords: RIPK3-IN-1 supplier, RIPK, inhibitors, activators


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