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Ripasudil (K-115) dihydrate

Cat. No. M5933
Ripasudil (K-115) dihydrate Structure
Synonym:

K-115

Size Price Availability Quantity
5mg USD 195  USD195 In stock
10mg USD 315  USD315 In stock
25mg USD 700  USD700 In stock
50mg USD 1185  USD1185 In stock
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Quality Control & Documentation
Biological Activity

Ripasudil (K-115) hydrochloride dihydrate is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.

Chemical Information
Molecular Weight 395.88
Formula C15H23ClFN3O4S
CAS Number 887375-67-9
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yamamoto K, et al. Invest Ophthalmol Vis Sci. The novel Rho kinase (ROCK) inhibitor K-115: a new candidate drug for neuroprotective treatment in glaucoma.

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Keywords: Ripasudil (K-115) dihydrate, K-115 supplier, ROCK, inhibitors, activators


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