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Cat. No. M9165
Rimegepant Structure

BMS-927711; BHV-3000

Size Price Availability Quantity
2mg USD 80  USD80 In stock
5mg USD 150  USD150 In stock
10mg USD 240  USD240 In stock
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Quality Control
Biological Activity

Rimegepant, also known as BMS-927711, is a potent, selective, competitive, and orally active calcitonin gene-related peptide (CGRP) antagonist with a Ki value of 0.027 nM. Rimegepant has shown in vivo efficacy without vasoconstriction effect. BMS-927711 is superior to placebo at several different doses (75 mg, 150 mg, and 300 mg) and has an excellent tolerability profile. The compound is unstable in solutions, freshly prepared is recommended.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 534.56
Formula C28H28F2N6O3
CAS Number 1289023-67-1
Purity 98.17%
Solubility DMSO 9 mg/mL
Ethanol 9 mg/mL
Storage Powder

[1] Zheng N, et al. J Pharm Biomed Anal. Improved liquid-liquid extraction with inter-well volume replacement dilution workflow and its application to quantify BMS-927711 in rat dried blood spots by UHPLC-MS/MS.

[2] Zheng N, et al. J Pharm Biomed Anal. A rapid, accurate and robust UHPLC-MS/MS method for quantitative determination of BMS-927711, a CGRP receptor antagonist, in plasma in support of non-clinical toxicokinetic studies.

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Keywords: Rimegepant, BMS-927711; BHV-3000 supplier, CGRP Receptor, inhibitors

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