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RGD peptide (GRGDNP) (TFA)

Cat. No. M10557
RGD peptide (GRGDNP) (TFA) Structure
Synonym:

GRGDNP TFA

Size Price Availability Quantity
5mg USD 115  USD115 In stock
10mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

RGD peptide TFA acts as an inhibitor of integrin-ligand interactions and plays an important role in cell adhesion, migration, growth, and differentiation. RGD peptide TFA promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing.

Chemical Information
Molecular Weight 728.63
Formula C25H39F3N10O12
CAS Number 114681-65-1 (free base)
Solubility (25°C) Water ≥ 50 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] J E Meredith Jr, et al. Trends Cell Biol. Integrins, adhesion and apoptosis

[2] W Yang, et al. J Biol Chem. Activation of the Cdc42-associated tyrosine kinase-2 (ACK-2) by cell adhesion via integrin beta1

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Keywords: RGD peptide (GRGDNP) (TFA), GRGDNP TFA supplier, Integrin, inhibitors, activators


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