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Retro-2

Cat. No. M8438
Retro-2 Structure
Size Price Availability Quantity
5mg USD 120  USD120 In stock
10mg USD 190  USD190 In stock
25mg USD 345  USD345 In stock
50mg USD 570  USD570 In stock
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Quality Control & Documentation
Biological Activity

Retro-2 inhibits ebolavirus infection with an EC50 value of 12.2 uM and reduces ricin-induced toxicity by 2.7-fold when used at a concentration of 20 uM in HeLa cells. Retro-2 also blocks JC polyomavirus, BK polyomavirus, and SV40 infectivity in Vero green monkey kidney epithelial cells in vitro (EC50s = 28.4, 61.2, and 58.6 uM, respectively).

In mouse models, Retro-2 improves survival and reduces symptoms following infection with Shiga toxin-producing E. coli when administered at a dose of 100 mg/kg and protects against ricin challenge when administered prophylactically at a dose of 2 mg/kg.

Chemical Information
Molecular Weight 320.41
Formula C19H16N2OS
CAS Number 1429192-00-6
Form Solid
Solubility (25°C) DMSO: 10 mg/mL (warmed)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhouguang Jiao, et al. Pretreatment with Retro-2 protects cells from death caused by ricin toxin by retaining the capacity of protein synthesis

[2] Hesso Farhan. Rendezvous of Retro-2 at the ER

[3] Wen Dai, et al. Antiviral Effect of Retro-2.1 against Herpes Simplex Virus Type 2 In Vitro

[4] Olena Shtanko, et al. Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infection

[5] Wenwen Dai, et al. Antiviral effects of Retro-2 cycl and Retro-2.1 against Enterovirus 71 in vitro and in vivo

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