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Resminostat

Cat. No. M2095
Resminostat Structure
Synonym:

4SC-201, RAS2410

Size Price Availability Quantity
10mg USD 200 In stock
50mg USD 640 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Resminostat (4SC-201) is a novel, orally bioavailable histone deacetylase (HDAC) inhibitor for the treatment of cancers. Resminostat inhibited proliferation and induced G0/G1 cell cycle arrest in 3 out of 4 MM cell lines accompanied with decreased levels of cyclin D1, cdc25a, Cdk4 and pRb as well as upregulation of p21 at 1 micromol/l. Resminostat (4SC-201) induces hyperacetylation of histone H4 in MM cells. Low micromolar concentrations of resminostat (RAS2410) abrogated cell growth and strongly induced apoptosis (IC50=2.5-3 micromol/l in 3 out of 4 MM cell lines) in MM cell lines as well as primary MM cells. Resminostat decreased phosphorylation of 4E-BP1 and p70S6k indicating an interference with Akt pathway signalling. Resminostat treatment resulted in increased protein levels of Bim and Bax and decreased levels of Bcl-xL.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 349.41
Formula C16H19N3O4S
CAS Number 864814-88-0
Purity >98%
Solubility DMSO
Storage at -20°C
References

The novel inhibitor of histone deacetylase resminostat (RAS2410) inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells.
Mandl-Weber S, et al. Br J Haematol. 2010 May;149(4):518-28. PMID: 20201941.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Resminostat, 4SC-201, RAS2410 supplier, HDAC, inhibitors

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