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Repaglinide

Cat. No. M3714
Repaglinide Structure
Synonym:

AG-EE, 623ZW

Size Price Availability Quantity
50mg USD 85 In stock
100mg USD 135 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Repaglinide is a short-acting insulin secretagogue, which often results in considerable inter-individual variability in therapeutic efficacy when widely used in clinical setting. Repaglinide is used for diabetes mellitus type 2. Both repaglinide and metformin were effective in glycaemic control in new onset patients with type 2 diabetes in China. Repaglinide had no effect on insulin sensitivity, but it improved β-cell function.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 452.59
Formula C27H36N2O4
CAS Number 135062-02-1
Purity >99%
Solubility DMSO
Storage at -20°C
References

PPARD rs2016520 Polymorphism Affects Repaglinide Response in Chinese Han Patients with Type 2 Diabetes Mellitus.
Song JF, et al. Clin Exp Pharmacol Physiol. 2014 Oct 14. PMID: 25311380.

Comparison of metformin and repaglinide monotherapy in the treatment of new onset type 2 diabetes mellitus in China.
Ma J, et al. J Diabetes Res. 2014;2014:294017. PMID: 25311380.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Repaglinide, AG-EE, 623ZW supplier, Potassium Channel, inhibitors

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