Repaglinide is a short-acting insulin secretagogue, which often results in considerable inter-individual variability in therapeutic efficacy when widely used in clinical setting. Repaglinide is used for diabetes mellitus type 2. Both repaglinide and metformin were effective in glycaemic control in new onset patients with type 2 diabetes in China. Repaglinide had no effect on insulin sensitivity, but it improved β-cell function.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
PPARD rs2016520 Polymorphism Affects Repaglinide Response in Chinese Han Patients with Type 2 Diabetes Mellitus.
Song JF, et al. Clin Exp Pharmacol Physiol. 2014 Oct 14. PMID: 25311380.
Comparison of metformin and repaglinide monotherapy in the treatment of new onset type 2 diabetes mellitus in China.
Ma J, et al. J Diabetes Res. 2014;2014:294017. PMID: 25311380.
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