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Regorafenib HCl

Cat. No. M5925
Regorafenib HCl Structure
Size Price Availability Quantity
5mg USD 90 In stock
10mg USD 150 In stock
50mg USD 380 In stock
100mg USD 600 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 519.28
Formula C21H16Cl2F4N4O3
CAS Number 835621-07-3
Purity >98%
Solubility 5.6 mg/mL in DMSO
Storage at -20°C
References

Regorafenib-associated hand-foot skin reaction: practical advice on diagnosis, prevention, and management.
McLellan B, et al. Ann Oncol. 2015 Oct;26(10):2017-26. PMID: 26034039.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Regorafenib HCl supplier, VEGFR/PDGFR, inhibitors

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