Recombinant Rat IL-4 Protein is a multidirectional cytokine that regulates various T cell and B cell responses such as cell proliferation, survival, and gene expression. IL-4 is produced by mast cells, T cells and bone marrow stromal cells, and regulates the differentiation of naive CD4+ T cells into helper Th2 cells. Its cytokine secretion features include secretion of IL-4, IL-5, IL-6, and IL- 10 and IL-13, are conducive to humoral immune response. The other main function of IL-4 is to regulate the conversion of immunoglobulins into IgG 1 and IgE subtypes.
Depends on its ability to stimulate the proliferation of TF-1 cells, the expected ED50 is 200~400 ng/ml.
Expression host is Human HEK293 cells
| Solubility (25°C) | Water Saline PBS |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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