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Recombinant Mouse BMP-4 Protein (HEK293, rFc Tag)

Cat. No. M10021
Recombinant Mouse BMP-4 Protein (HEK293, rFc Tag) Structure
Synonym:

Bmp-4 Protein Mouse

Size Price Availability Quantity
10ug USD 300  USD300 In stock
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Quality Control & Documentation
  • Purity: ≥95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Recombinant Mouse BMP-4 Protein is a TGF-beta superfamily ligand that is widely expressed from early embryogenesis through adulthood. Mouse BMP-4 shares 85% aa sequence identity with mouse BMP-2 and 35%-54% with other mouse BMPs. BMP-4 signals through tetrameric complexes composed of type I (primarily Activin RIA or BMPR-IA) and type II (primarily Activin RIIA or BMPR-II) receptors . The bioavailability of BMP-4 is regulated by its interaction with multiple proteins and glycosaminoglycans.

The recombinant mouse BMP4 consists 365 amino acids and predicts a molecular mass of 40.6 kDa. A DNA sequence encoding the mouse BMP4 (Ser293-Arg408) was expressed with the Fc region of rabbit IgG at the N-terminus.


Endotoxin < 1 EU/µg

Lyophilized from sterile PBS, pH 7.4, 5% Trehalose, 5% Mannitol, 0.01% Tween-80.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in distilled water up to 150 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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