Species: Mouse
Expression system: E.coli
Purity: > 95% as determined by reduced SDS-PAGE
Molecular weight: 12.6 KDa
Endotoxin: LAL test measured less than 0.1 ng/µg (1EU/µg)
Storage and stability: The freeze-dried protein should be stored at ≤-20°C for one year after receiving. The recombinant protein solution can be stored at 2-8℃ for 2-7 days. The bisector of the recombinant sample was stable at ≤-20°C for 3 months
Bioactivity: Protein S100-A11(S100A11) is a member of the S-100 family. S100A11 is widely expressed in a variety of tissues, distributed in cytoplasm, nucleus and even peripheral cells. S100A11 exists as a noncovalent homodimer with antiparallel conformation. Binding of Ca(2+) to S100A11 causes conformational changes that expose hydrophobic gaps in S100A11 and facilitate its interaction with target proteins. As a two-cell growth medium, S100A11 acts as both a tumor suppressor and a tumor promoter in many different types of tumors, and plays its respective role in influencing cancer cell proliferation proteins. In the nucleus, S100A11 inhibits keratinocyte growth and induces cell differentiation by activating p21 (CIP1/WAF1). S100A11 is also a new diagnostic marker for breast cancer.
| Solubility (25°C) | It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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