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Recombinant Mouse IL-7 (CHO, His)

Cat. No. M21610
Recombinant Mouse IL-7 (CHO, His) Structure
Synonym:

interleukin 7; IL7

Size Price Availability Quantity
10ug USD 200  USD200 In stock
50ug USD 750  USD750 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Recombinant Mouse IL-7 (Interleukin-7), also known as lymphopoietin 1 and pre-B cell factor, is a hematopoietic growth factor belonging to the IL-7/IL-9 family. It is produced by keratinocytes, dendritic cells, hepatocytes, neurons and epithelial cells. IL-7 binds and signals through IL-7 receptor, a heterodimer consisting of IL-7 receptor alpha and common gamma chain receptor. IL-7 plays a role in regulating early B cell and T cell development.

ED50 is < 0.4 ng/ml, measured in a cell proliferation assay using 2E8 cells.

Apparent Molecular Weight: 8~28kDa, on SDS-PAGE under reducing conditions.

Customer Product Validations & Biological Datas
Source Customer Feedback
Method cell proliferation assay
Cell Lines 2E8 cells
Concentrations
Incubation Time
Results Measured in a cell proliferation assay using 2E8 cells, ED₅₀ is <0.4 ng/ml.
Chemical Information
Solubility (25°C) Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Miriam Y Kim, et al. Nat Commun. A long-acting interleukin-7, rhIL-7-hyFc, enhances CAR T cell expansion, persistence, and anti-tumor activity

[2] Jian L Campian, et al. Clin Cancer Res. Long-Acting Recombinant Human Interleukin-7, NT-I7, Increases Cytotoxic CD8 T Cells and Enhances Survival in Mouse Glioma Models

[3] Juan Huang, et al. Front Immunol. The Broad Immunomodulatory Effects of IL-7 and Its Application In Vaccines

[4] Hyein Jeong, et al. J Immunother Cancer. Recombinant Mycobacterium smegmatis delivering a fusion protein of human macrophage migration inhibitory factor (MIF) and IL-7 exerts an anticancer effect by inducing an immune response against MIF in a tumor-bearing mouse model

[5] Jifeng Zhu, et al. J Cell Mol Med. IL-7 suppresses macrophage autophagy and promotes liver pathology in Schistosoma japonicum-infected mice

[6] Yang Xu, et al. Blood. Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15

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Keywords: Recombinant Mouse IL-7 (CHO, His), interleukin 7; IL7 supplier, Recombinant Proteins, inhibitors, activators


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