Interleukin-21 (IL-21) is a approximately 14kda cytokine belonging to the IL-15/IL-21 family. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It plays its biological role through the heterodimer receptor complex (IL-21 specific il-21r). IL-21 is a cytokine that has a powerful regulatory effect on the cells of the immune system, including natural killer cells (NK) and cytotoxic T cells that can destroy viral infections or cancer cells. This cytokine induces cell division/proliferation in target cells. It is required for the migration of dendritic cells to draining lymph nodes, and it jointly stimulates the activation, proliferation and survival of CD8+ T cells and NKT cells, and promotes the polarization of Th17 cells. It blocks the production of regulatory T cells and its inhibitory effect on CD4+ T cells.
Accession: Q9ES17
APMol Mass: 16 KDa, reducing conditions
Endotoxin < 1 EU/µg
Lyophilized from a 0.2 μm filtered solution of 20mM Histidine-HCl, 6% Sucrose, 2% Glycine, 50mM NaCl, 0.05% Tween 80, pH 6.5.
| Form | Lyophilized powder |
| Solubility (25°C) | Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at ≤ -20°C for 3 months. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Anusha Kalbasi, et al. Nature. Potentiating adoptive cell therapy using synthetic IL-9 receptors
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