Interleukin 2 (IL 2), also known as T-cell growth factor, is a member of a family of cytokines that includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signaling is transmitted through the IL-2 receptor, a complex of tree-like subunits called alpha, beta, and gamma. IL-2 is produced by CD4+ T cells, CD8+ T cells, γδT cells, B cells, dendritic cells and eosinophils, and plays an important role in key functions of the immune system, tolerance and immunity, mainly through its powerful stimulatory activity on T cells. Thus, IL-2 may be a key cytokine that naturally suppresses autoimmunity.
Recombinant Mouse Interleukin-2 is produced by E.coli expression system, and expressed the target gene encoding Ala21-Gln169.
Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells, the specific activity of Recombinant Mouse IL-2 is ≥1×107 IU/mg.
Accession: P04351
Endotoxin < 0.01 EU/µg
Apparent Molecular Weight: 17 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of 20mM Sodium Citrate, 0.2% Tween 80, pH 3.0.
Immun Inflamm Dis. 2023 Sep;11(9):e1011.
Dendritic cells infected with recombinant adenoviral vector encoding mouse fibroblast activation protein-α and human livin α exert an antitumor effect against Lewis lung carcinoma in mice
Recombinant Mouse IL-2 (E.coli) purchased from AbMole
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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