Expression system: CHO
Purity: >95% by SDS-PAGE analysis
Endotoxin: < 0.2 EU/μg of protein by gel coagulation
Apparent molecular weight: 27~29 kDa (p35), 45~50 kDa (p40) on SDS-PAGE under reducing conditions
Storage and Stability: This product is stable for up to 6 months after receipt at temperatures below -70°C. After reconstitution, this product should be stable for 1 week at 4°C or 3 months at -20°C. For long-term storage, the addition of a carrier protein (e.g. 0.1% BSA) is recommended. Avoid repeated freeze-thaw cycles.
Bioactivity: It is produced by monocytes, macrophages, B cells and dendritic cells in response to bacterial lipopolysaccharides and intracellular pathogens.IL-12 signals through the IL-12 receptor complex, which consists of IL-12 Rβ1 and IL-12 Rβ2.IL-12 induces proliferation and activation of hematopoietic stem cells, natural killer cells and T cells. It is essential in the development of Th1 cells, leading to the production of IFN-gamma and IL-2.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Purity||>95% , Endotoxin < 0.2 EU/μg|
|Solubility||Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml.|
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