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Recombinant Mouse IL-12 (CHO)

Cat. No. M21278
Recombinant Mouse IL-12 (CHO) Structure
Synonym:

IL12; NKSF; TCMF; CLMF; TSF

Size Price Availability Quantity
10ug USD 160  USD200 In stock
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Quality Control
  • Current batch:
  • Purity >95% , Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Species: Mouse
Expression system: CHO
Purity: >95% by SDS-PAGE analysis
Endotoxin: < 0.2 EU/μg of protein by gel coagulation
Apparent molecular weight: 27~29 kDa (p35), 45~50 kDa (p40) on SDS-PAGE under reducing conditions
Storage and Stability: This product is stable for up to 6 months after receipt at temperatures below -70°C. After reconstitution, this product should be stable for 1 week at 4°C or 3 months at -20°C. For long-term storage, the addition of a carrier protein (e.g. 0.1% BSA) is recommended. Avoid repeated freeze-thaw cycles.


Bioactivity: It is produced by monocytes, macrophages, B cells and dendritic cells in response to bacterial lipopolysaccharides and intracellular pathogens.IL-12 signals through the IL-12 receptor complex, which consists of IL-12 Rβ1 and IL-12 Rβ2.IL-12 induces proliferation and activation of hematopoietic stem cells, natural killer cells and T cells. It is essential in the development of Th1 cells, leading to the production of IFN-gamma and IL-2.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95% , Endotoxin < 0.2 EU/μg
Solubility Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml.
Storage at -20°C
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Keywords: Recombinant Mouse IL-12 (CHO), IL12; NKSF; TCMF; CLMF; TSF supplier, Cytokines, inhibitors

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