Recombinant Human SCF Protein is a hematopoietic growth factor that exerts its activity through c-Kit receptor signaling. SCF and c-Kit are essential to support the survival, proliferation and differentiation of melanocytes and hematopoietic cells of the germ cell line. Human SCF has low activity on mouse cells, while mouse and rat SCF have sufficient activity on human cells. The human SCF gene encodes a 273 amino acid transmembrane protein, including 25 amino acid N-terminal signal sequences, 189 amino acid extracellular domains, 23 amino acid transmembrane domains and 36 amino acid cytoplasmic domains.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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| Recombinant Human IL-36 gamma/IL-1 F9 Protein (E. coli, aa 18-169, His Tag)
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| Recombinant Human IL-36 gamma/IL-1 F9 Protein (E. coli)
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| Recombinant Human KGF/FGF-7 Protein (E. coli, His Tag)
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