Scavenger Receptor Class B Member 2 (SCARB2) is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Recombinant Human Scavenger Receptor Class B Member 2 (SCARB2) is produced by Mammalian expression system and the target gene encoding Arg27-Thr432 is expressed with a 6His tag at the C-terminus. SCARB2 may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. In addition, SCARB2 also has been shown to bind thrombospondin-1, may contribute to the pro-adhesive changes of activated platelets during coagulation, and inflammation.
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water to a concentration of 100μg/ml |
| Storage | Stored at ≤ -20°C, stable for one year after receipt |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] T Xu, et al. Acta Virol. Prokaryotic expression and identification of scavenger receptor B2
[5] Yi-Wen Lin, et al. PLoS One. Human SCARB2-mediated entry and endocytosis of EV71
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