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Recombinant Human Lipocalin-2/NGAL/LCN2 (E. coli, C-6His)

Cat. No. M21202
Recombinant Human Lipocalin-2/NGAL/LCN2 (E. coli, C-6His) Structure
Synonym:

Neutrophil gelatinase-associated lipocalin; NGAL

Size Price Availability Quantity
10ug USD 165  USD165 In stock
50ug USD 360  USD360 In stock
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Quality Control & Documentation
  • Purity: >90%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Neutrophil gelatinase-associated lipocalin (LCN2) is a secreted protein that belongs to the kallikrein superfamily. This protein is released from injured renal tubular cells after various destructive stimuli and has been described by nephrologists as one of the most promising biomarkers of afferent acute kidney injury (AKI). Recent evidence also suggests its role as a biomarker in various other renal and non-renal diseases. In addition, recent studies seem to indicate that this factor may also be involved in the development and progression of chronic kidney disease.NGAL is the first known mammalian protein that specifically binds organic molecules called glycosides, which are high-affinity iron chelators.NGAL was first known as an antimicrobial factor of natural immunity and an acute phase protein, and is currently one of the most interesting and enigmatic proteins. As an intracellular iron carrier and protector of MMP9 from proteolysis, NGAL has a significant pro-tumor effect and has been observed in different human tumors (e.g. breast, stomach, esophagus, brain). In thyroid cancer, NGAL is strongly induced by NF-kB, an important factor involved in the link between tumor growth and chronic inflammation and tumor development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in various processes, including cell differentiation, proliferation, survival, and morphogenesis.


Endotoxin <1 EU/µg

Molecular weight: 21.8 KDa

Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH 7.4.

The product is shipped on dry ice/polar packs.

Upon receipt, store it immediately at the temperature listed below.

Chemical Information
Form Solution
Solubility (25°C) You can dilute the product with Sterile PBS solution
Storage Store at ≤ -70°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jianwei Wu, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. [Prokaryotic expression and immunological activity of human neutrophil gelatinase associated lipocalin]

[2] Zahra Bakhshandeh, et al. Hematology. Recombinant human lipocalin 2 acts as an antibacterial agent to prevent platelet contamination

[3] Marcus Miethke, et al. Antimicrob Agents Chemother. Neutrophil gelatinase-associated lipocalin expresses antimicrobial activity by interfering with L-norepinephrine-mediated bacterial iron acquisition

[4] Marianne Valdebenito, et al. FEMS Microbiol Lett. Special conditions allow binding of the siderophore salmochelin to siderocalin (NGAL-lipocalin)

[5] J R Bundgaard, et al. Biochem Biophys Res Commun. Molecular cloning and expression of a cDNA encoding NGAL: a lipocalin expressed in human neutrophils

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Keywords: Recombinant Human Lipocalin-2/NGAL/LCN2 (E. coli, C-6His), Neutrophil gelatinase-associated lipocalin; NGAL supplier, Recombinant Proteins, inhibitors, activators


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