Recombinant human/mouse/rat Activin A protein is A multifunctional cytokine belonging to transforming growth factor β (TGF β) superfamily. It is associated with a variety of pathophysiological processes, including inflammation, fibrosis, and tumorigenesis.
Measured by its ability to induce SMAD signaling in 293-Activin A Res cells, the ED50 for this effect is 1.3 ng/ml.
Measured by its ability to induce hemoglobin expression in K562 human chronic myelogenous leukemia cells, the ED50 for this effect is ~1.2 ng/mL.
Endotoxin < 0.01 EU/µg
Apparent Molecular Weight: 14-15 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of 4mM HCl.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at ≤ -20°C for 3 months. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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