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Recombinant Human/Mouse/Rat TGFB3(Mammalian)

Cat. No. M19995
Recombinant Human/Mouse/Rat TGFB3(Mammalian) Structure
Synonym:

Transforming growth factor beta-3; TGFB3

Size Price Availability Quantity
10ug USD 224  USD280 In stock
50ug USD 640  USD800 In stock
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Quality Control
  • Current batch:
  • Purity >95% , Endotoxin < 0.01 EU/µg
  • COA
  • MSDS
Biological Activity

Species: the Human/Mouse/Rat
Expression system: Mammalian
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: LAL test < 0.001 ng/µg (0.01 EU/µg)
Apparent molecular weight: 12-14 kDa, reduction conditions
Storage and Stability: lyophilized proteins should be stored at < -20°C, but can be stored for up to 3 weeks at room temperature. The recombinant protein solution can be stored at 4-7 ° C for 2-7 days. Aliquots of recombinant samples were stable at < -20°C for 3 months.


Bioactivity: Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3,mammals develop a deformity known as a cleft palate.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95% , Endotoxin < 0.01 EU/µg
Solubility It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage at -20°C
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Keywords: Recombinant Human/Mouse/Rat TGFB3(Mammalian), Transforming growth factor beta-3; TGFB3 supplier, Cytokines, inhibitors

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