Expression system: Mammalian
Purity: >95% by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/µg (1 EU/µg) by LAL test
Molecular weight: 39.7 KDa
Storage and Stability: Lyophilized proteins should be stored at <-20°C, although stable at room temperature for up to 3 weeks. Reconstituted protein solutions can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable for 3 months at <-20°C.
Bioactivity: Protein 5 containing the fibronectin type III structural domain, a precursor of irisin, is a protein encoded by the FNDC5 gene. Human irisin is synthesized as a 212 amino acid (aa) precursor encoding a type 1 transmembrane protein with 121 extracellular structural domains (ECDs), 21 transmembrane structural domains and 39 cytoplasmic structural domains. the ECD of Irisin contains a fibronectin type III structural domain and multiple glycosylation sites. irisin induces peroxisome proliferator-activated receptor γ Irisin also regulates neuronal differentiation and neuronal growth in the brain and is involved in the differentiation of osteoblasts.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Purity||>95% , Endotoxin < 1 EU/µg|
|Solubility||It is not recommended to reconstitute to a concentration less than 100μg/ml.|
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