Activin and inhibin are two closely related protein complexes with almost direct opposite biological effects. Activin, a member of the TGF - β superfamily, is a disulfide bonded dimer protein originally purified from gonadal fluid as a protein that stimulates the release of pituitary follicle stimulating hormone (FSH). Statins/activins are involved in regulating many different functions, such as thalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythrocyte differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Activins are homo-dimers or heterodimers of various β subtypes, while inhibin is a unique α subunit and one of various β subunits.
Measured by its ability to induce SMAD signaling in 293-Activin A Res cells, the ED50 for this effect is 1.3 ng/ml.
Accession: P08476
APMol Mass: 15 KDa, reducing conditions
Endotoxin < 0.01 EU/µg
Lyophilized from a 0.2 μm filtered solution of 4mM HCl.
Form | Lyophilized powder |
Solubility (25°C) | Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at ≤ -20°C for 3 months. |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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