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Recombinant Human MCP-1 (CCL2)

Cat. No. M9861
Recombinant Human MCP-1 (CCL2) Structure
Size Price Availability Quantity
50ug USD 400  USD400 In stock
100ug USD 650  USD650 In stock
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Quality Control & Documentation
  • Purity: ≥95%, Endotoxin ≤0.01EU/ug
  • COA
  • MSDS
Biological Activity

Recombinant Human MCP-1 (CCL2) is a member of the CC chemokine family and signals through CCR 2 and other CCR receptors except MCP-1, it chemotactically activates monocytes, activated T cells, basophils, NK cells and immature dendritic cells. The MCP family cross-reacts across species. Recombinant human MCP-1 is an 8.6kDa protein containing 76 amino acid residues, of which 4 highly conserved cysteine residues are present in CC chemokines.

Chemical Information
Solubility (25°C) Water
Saline
PBS
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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