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Recombinant Human IL-8/CXCL8 (77aa, E. coli)

Cat. No. M15036
Recombinant Human IL-8/CXCL8 (77aa, E. coli) Structure
Synonym:

Interleukin-8; GCP-1; NAP-1; MDNCF

Size Price Availability Quantity
5ug USD 122  USD122 In stock
25ug USD 250  USD250 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Interleukin-8 (IL-8), also known as CXCL8, exists in two forms: a 77 a.a. protein produced by endothelial cells, and the more active 72 a.a. protein produced by monocytes in vivo. Il-8 receptors are 7 helical G protein-coupled receptors CXCR1 and CXCR2 and are expressed only on neutrophils. The function of IL-8 is to induce rapid changes in cell morphology, activate integrins, and release neutrophil particle content. Therefore, IL-8 can enhance the antibacterial action of defense cells. It is secreted by monocytes, macrophages and endothelial cells. Il-8 signaling attracts neutrophils, basophils, and T cells via CXCR1 and CXCR2. Il-8 is also a potent promoter of angiogenesis.

The EC50 value of human IL-8(77aa) on Ca2+ mobilization assay in CHO-K1/G15/hCXCR1 cells is less than 150.0 ng/ml.


Accession: P10145

Endotoxin < 0.2 EU/μg

Apparent Molecular Weight: ~8.9 kDa, reducing conditions

Lyophilized after extensive dialysis against PBS.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Recombinant Human IL-8/CXCL8 (77aa, E. coli), Interleukin-8; GCP-1; NAP-1; MDNCF supplier, Recombinant Proteins, inhibitors, activators


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