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Recombinant Human IL-6R (CHO)

Cat. No. M11359
Recombinant Human IL-6R (CHO) Structure
Synonym:

IL-6RA; IL-6R1; CD126; IL-6RA

Size Price Availability Quantity
10ug USD 190  USD190 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Interleukin-6 receptor α, also known as IL-6RA, IL-6R1 and CD126, is a member of the type I cytokine receptor family. Mainly expressed in T cells, fibroblasts and macrophages. Il-6ra is coupled with GP130 to form IL-6 receptor. Il-6ra binds specifically to IL-6 and depends on GP130 for signaling. Il-6ra dysfunction is associated with the pathogenesis of multiple myeloma, autoimmune diseases, prostate cancer and other diseases. Soluble IL-6RA, composed only of the extracellular domain of IL-6RA, acts as an agonist of IL-6 activity.

Measured in a cell proliferation assay using M1 cells in the presence of 10.0 ng/ mL human IL-6, the ED50 is < 0.2 μg/mL.


Accession: P08887

Apparent Molecular Weight: 54~56 kDa, reducing conditions

Expression System: CHO

Endotoxin < 0.2 EU/μg

Lyophilized after extensive dialysis against PBS.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O or PBS to 100 μg/ml.
Storage Stable for up to 6 months at ≤ -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yukio Takamori, et al. Biochem Biophys Res Commun. In vitro display evolution of IL-6R-binding unnatural peptides ribosomally initiated and cyclized with m-(chloromethyl)benzoic acid

[2] Paul Baran, et al. J Biol Chem. The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling

[3] Martin Sheppard, et al. Hum Vaccin Immunother. Tocilizumab (Actemra)

[4] Michelle Rothaug, et al. Biochim Biophys Acta. The role of interleukin-6 signaling in nervous tissue

[5] Stefan Rose-John, et al. Expert Opin Ther Targets. The IL-6/sIL-6R complex as a novel target for therapeutic approaches

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Keywords: Recombinant Human IL-6R (CHO), IL-6RA; IL-6R1; CD126; IL-6RA supplier, Recombinant Proteins, inhibitors, activators


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