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Recombinant human IL-6 (CHO-expressed)

Cat. No. M9364
Recombinant human IL-6 (CHO-expressed) Structure
Synonym:

Interleukin-6; rhIL-6

Size Price Availability Quantity
50ug USD 610  USD610 In stock
100ug USD 890  USD890 In stock
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Quality Control & Documentation
Biological Activity

Recombinant Human IL-6 is an interleukin that in humans is encoded by the IL-6 gene and acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 binds to IL-6 receptor (IL-6R) to trigger the association of IL-6R with gp130, inducing signal transduction through JAKs and STATs. The biological functions of IL-6 are diverse. It stimulates B cell differentiation and antibody production, myeloma and plasmacytoma growth, as well as nerve cell differentiation. It also acts as a myokine, produced by muscle cells in response to muscle contraction, to be released to the blood stream to help break down fats and improve insulin resistance.

The ED50 is <0.1 ng/mL as measured by murine 7TD1 cells, corresponding to a specific activity of 5 × 107 units/mg.

Chemical Information
Solubility (25°C) Water
Saline
PBS
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Recombinant human IL-6 (CHO-expressed), Interleukin-6; rhIL-6 supplier, Recombinant Proteins, inhibitors, activators


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