Recombinant Human IL-10 Protein (Interleukin-10) (HEK 293) is an immunosuppressive cytokine produced by a variety of mammalian cell types, including macrophages, monocytes, T cells, B cells, and keratinocytes. Interleukin-10 (IL-10) inhibits the expression of IL-1 and TNF-α and other pro-inflammatory cytokines. Like IL-4, IL-10 enhances the humoral immune response and weakens the cell-mediated immune response. Human Interleukin-10 pairs Mouse cells are active, while mouse interleukin-10 has no activity on human cells.
Expression host
Human HEK293 cells
| Solubility (25°C) | Water Saline PBS |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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