Human IFN-α2a and -α2b (HEK293) are allelic variants of the same gene, the IFN-α subtype is classified as an intermediate/strong ISG inducer and has strong antiviral activity against influenza A virus. Human IFN-α2b can be co-cultured with cpg oligonucleotide or imimiquimod in peripheral blood mononuclear cells (PBMCs), and induced in plasmacytoid dendritic cells. Recombinant human IFN-α2 is the only clinically approved subtype of IFN-α. Both IFN-α2a and IFN-α2b are used to treat chronic hepatitis B or C, hairy cell leukemia and other forms of cancer.
Expression host is HEK293 cells
Endotoxin <1EU/ug
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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