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Recombinant Human FGF-8b Protein (HEK293, C-Fc)

Cat. No. M10003
Recombinant Human FGF-8b Protein (HEK293, C-Fc) Structure
Synonym:

Fibroblast Growth Factor-8b

Size Price Availability Quantity
20ug USD 180  USD180 In stock
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Quality Control & Documentation
  • Purity: ≥95%, Endotoxin ≤0.01EU/ug
  • COA
  • MSDS
Biological Activity

Recombinant Human FGF-8b Protein is a heparin-binding growth factor, which plays a core role in prenatal development, postnatal growth and regeneration of various tissues by promoting cell proliferation and other effect. FGF-8 (FGF-8b) belongs to the FGF family. Human and mouse FGF-8A and B are exactly the same, while human and mouse FGF-8E and F are 98% identical. FGF-8 mainly targets breast cancer cells and other cells that express FGF receptors.

The recombinant human FGF-8b protein contains 431 amino acids and the predicted molecular weight is 49.3kd.

Determined by the dose-dependent stimulation effect of thymine expressing FGF receptor in BaF3 cells, ED50 value should be ≤1 ng/ml, combined with its specific activity ≥1×106 IU/mg.

Expression host is Human HEK293 cells

Chemical Information
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O or PBS to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Recombinant Human FGF-8b Protein (HEK293, C-Fc), Fibroblast Growth Factor-8b supplier, Recombinant Proteins, inhibitors, activators


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