Species: Homo sapiens (Human)
Predicted molecular weight: 33.46 kDa
Purity: sdS-PAGE determination was >90%
Stability and storage: use manual defrosting refrigerator to avoid repeated freeze-thaw cycles. Store at 2-8 °C for one week. Store at -20 to -80°C for 12 months from date of receipt.
Biological activity: Can activate a variety of chemokine receptors, including CCR1, CCR3, CCR4 and CCR5. A major HIV suppressor is produced by CD8+ T cells. Recombinant RANTES protein induces dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). As a natural chemotactic inhibitor, processed RANTES(3-68) is a more potent inhibitor of HIV-1 infection. The second treated RANTES(4-68), which is produced by an unknown enzyme associated with monocytes and neutrophils, showed lower chemotaxis and hiv-inhibiting activity compared to RANTES(1-68) and RANTES(3-68). It may also be an agonist of the G-protein-coupled receptor GPR75, through which activation stimulates inositol triphosphate production and calcium mobilization. Together with GPR75, it may play a role in neuronal survival by activating downstream signaling pathways involving PI3, Akt, and MAP kinases. Activation of GPR75 may also play a role in insulin secretion by islet cells.
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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