Species: Human
Purity: SDS-PAGE, > 95%
Endotoxin level: protein < 0.2 EU/μg by gel coagulation
Apparent molecular weight: ~43 kDa, sdS-PAGE under reduction conditions
Storage and stability: After receiving, the product remains stable at -20°C or below for 6 months and at 4°C for 1-2 weeks. For long-term storage, store at -70°C or below. Avoid repeated freeze-thaw cycles
Biological activity: Elevated cathepsin B levels occur in a variety of diseases, causing a variety of pathological changes, including cell death, inflammation, and toxic peptide production. For example, neuroscience studies have shown that cathepsin B plays a role in inducing epilepsy, leading to mass cell death. Epileptic seizure induced rats treated with cathepsin B inhibitors showed improved neural score and learning ability, and reduced neuronal cell death.
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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