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Recombinant Human BAFF Protein (CHO)

Cat. No. M9992
Recombinant Human BAFF Protein (CHO) Structure
Synonym:

B-cell Activating Factor; ZTNF4; TALL-1

Size Price Availability Quantity
10ug USD 140  USD140 In stock
50ug USD 390  USD390 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin <0.2 EU/ug
  • COA
  • MSDS
Biological Activity

Recombinant Human BAFF Protein is a member of the tumor necrosis factor (TNF) family and is expressed in T cells, macrophages, monocytes and dendritic cells, stimulating the functions of B cells and T cells, and is an important factor for the survival and maturation of peripheral B cells. BAFF signals through three different TNF receptors TACI, BCMA and BAFF-R.

Determined by dose-dependent mitogenic activity on human RPMI 8226 cells, the ED50 is < 20.0 ng/ml, corresponding to a specific activity of > 5.0 x 104 units/mg.


Accession: Q9Y275

Endotoxin < 0.2 EU/μg

Apparent Molecular Weight: ~17 kDa

Lyophilized after extensive dialysis against PBS.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O or PBS to 100 μg/ml.
Storage Stable for up to 6 months at ≤ -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Recombinant Human BAFF Protein (CHO), B-cell Activating Factor; ZTNF4; TALL-1 supplier, Recombinant Proteins, inhibitors, activators


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