Adiponectin antagonizes THF by negatively regulating THF expression. Adiponectin also inhibits endothelial NF-Kappa-B signaling through a camp-dependent pathway. Adiponectin can form low molecular weight complex (LMW), medium molecular weight complex (MMW) and high molecular weight complex (HMW). They bind to various growth factors, such as HBEGF, PDGFB and FGF2, and play a role in cell growth, angiogenesis and tissue remodeling.
Measured by M1 cell growth inhibition assay, the ED50 is < 20.0 μg/mL.
Accession # Q15848
Endotoxin < 0.2 EU/μg
Apparent Molecular Weight: 25~28 kDa, reducing conditions
Lyophilized after extensive dialysis against PBS.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[4] Jun Wada. Expert Opin Investig Drugs. Vaspin: a novel serpin with insulin-sensitizing effects
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