Expression host: human HEK293 cells
Molecular aliases: 4-1BB Ligand, TNFSF9, CD137L
Molecular weight: Recombinant human 4-1BB Ligand protein contains 467 amino acids and has a predicted theoretical molecular weight of 51kD
Purity: ≥95% Was analyzed by SDS-PAGE gel and HIGH performance liquid chromatography
Endotoxin: < 0.1EU/μg
Storage and stability: Lyophilized preparation can be stored at 4℃ for 24 months, dissolved liquid can be stored at -20℃ for 6-12 months, to avoid repeated freeze-thaw
Biological activity: Tumor necrosis factor ligand superfamily member 9 (4-1BBL) also known as 4-1BB ligand CD137L or TNFSF9, is a cytokine that binds TO TNFRSF9. 4-1BBL is a high affinity ligand of 4-1BB. 4-1BBL induced proliferation of activated peripheral blood T cells. In addition, 4-1BBL May play a role in activation-induced cell death (AICD). In addition, 4-1BBL May play a role in homologous interactions between T cells and B cells/macrophages. As for diseases, 4-1BBL is involved in cancer, infectious diseases and autoimmune diseases.
Solubility (25°C) | N/A |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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