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Recombinant Human 4-1BB Ligand Protein (HEK293)

Cat. No. M11391
Recombinant Human 4-1BB Ligand Protein (HEK293) Structure
Size Price Availability Quantity
50ug USD 650  USD650 In stock
100ug USD 1050  USD1050 In stock
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Quality Control & Documentation
  • Purity: ≥95% , Endotoxin <0.1EU/μg
  • COA
  • MSDS
Biological Activity

Expression host: human HEK293 cells
Molecular aliases: 4-1BB Ligand, TNFSF9, CD137L
Molecular weight: Recombinant human 4-1BB Ligand protein contains 467 amino acids and has a predicted theoretical molecular weight of 51kD
Purity: ≥95% Was analyzed by SDS-PAGE gel and HIGH performance liquid chromatography
Endotoxin: < 0.1EU/μg
Storage and stability: Lyophilized preparation can be stored at 4℃ for 24 months, dissolved liquid can be stored at -20℃ for 6-12 months, to avoid repeated freeze-thaw


Biological activity: Tumor necrosis factor ligand superfamily member 9 (4-1BBL) also known as 4-1BB ligand CD137L or TNFSF9, is a cytokine that binds TO TNFRSF9. 4-1BBL is a high affinity ligand of 4-1BB. 4-1BBL induced proliferation of activated peripheral blood T cells. In addition, 4-1BBL May play a role in activation-induced cell death (AICD). In addition, 4-1BBL May play a role in homologous interactions between T cells and B cells/macrophages. As for diseases, 4-1BBL is involved in cancer, infectious diseases and autoimmune diseases.

Chemical Information
Solubility (25°C) N/A
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shannon L McArdel, et al. Cancer Immunol Immunother. Anti-tumor effects of RTX-240: an engineered red blood cell expressing 4-1BB ligand and interleukin-15

[2] Shannon K Oda, et al. J Exp Med. A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy

[3] Angela C Boroughs, et al. Mol Ther. A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq

[4] Marta Trb, et al. J Immunother Cancer. Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer

[5] Nathalie Bonnefoy, et al. Med Sci (Paris). [Next generation of anti-immune checkpoints antibodies]

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