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Ranolazine

Cat. No. M5922

Ranolazine Structure

Synonym: CVT 303, RS 43285-003

Size Price Availability Quantity
50mg USD 70 In stock
100mg USD 100 In stock
500mg USD 250 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Ranolazine is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 427.54
Formula C24H33N3O4
CAS Number 95635-55-5
Purity >99%
Solubility 86 mg/mL in DMSO
Storage at -20°C
References

Effect of Ranolazine Monotherapy on Glycemic Control in Subjects With Type 2 Diabetes.
Eckel RH, et al. Diabetes Care. 2015 Jul;38(7):1189-96. PMID: 26049552.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ranolazine, CVT 303, RS 43285-003 supplier, Calcium Channel, inhibitors

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