Ranolazine is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||86 mg/mL in DMSO|
Effect of Ranolazine Monotherapy on Glycemic Control in Subjects With Type 2 Diabetes.
Eckel RH, et al. Diabetes Care. 2015 Jul;38(7):1189-96. PMID: 26049552.
|Related Calcium Channel Products|
|Dantrolene sodium salt
Inhibitor of Ca2+ release from sarcoplasmic reticulum; muscle relaxant.
Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium-channel complexes in the CNS.
L-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM.
Levosimendan is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.
Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine class.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.