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Ramosetron HCl

Cat. No. M5920
Ramosetron HCl Structure
Size Price Availability Quantity
10mg USD 60 In stock
50mg USD 150 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Ramosetron Hydrochloride(YM060 Hydrochloride) is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 315.8
Formula C17H18ClN3O
CAS Number 132907-72-3
Purity >99%
Solubility 22 mg/mL in DMSO
Storage at -20°C
References

Efficacy and safety of ramosetron versus ondansetron for postoperative nausea and vomiting after general anesthesia: a meta-analysis of randomized clinical trials.
Gao C, et al. Drug Des Devel Ther. 2015 Apr 23;9:2343-50. PMID: 25960637.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ramosetron HCl supplier, 5-HT Receptor, inhibitors

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