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Raltitrexed

Cat. No. M2224
Raltitrexed Structure
Synonym:

ZD1694; D1694; ICI-D1694

Size Price Availability Quantity
10mg USD 57  USD57 In stock
50mg USD 220  USD220 In stock
100mg USD 390  USD390 In stock
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Quality Control & Documentation
Biological Activity

Raltitrexed (Tomudex, ZD1694) is a novel quinazoline folate analog that selectively inhibits thymidylate synthase. Raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.

Chemical Information
Molecular Weight 458.49
Formula C21H22N4O6S
CAS Number 112887-68-0
Solubility (25°C) DMSO 78 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bernard Royer, et al. Exposure-response analysis of Raltitrexed assessing liver toxicity

[2] Y Liu, et al. Raltitrexed-based chemotherapy for advanced colorectal cancer

[3] Veerle F Surmont, et al. Raltitrexed in mesothelioma

[4] Kenneth S Wilson, et al. Raltitrexed: optimism and reality

[5] E Van Cutsem, et al. Raltitrexed: current clinical status and future directions

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Keywords: Raltitrexed, ZD1694; D1694; ICI-D1694 supplier, DNA/RNA Synthesis, inhibitors, activators


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