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R(+)-IAA-94

Cat. No. M11196
R(+)-IAA-94 Structure
Synonym:

R(+)-Methylindazone

Size Price Availability Quantity
10mg USD 115  USD115 In stock
50mg USD 370  USD370 In stock
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Biological Activity

R(+)-IAA-94 (R(+)-Methylindazone) is an effective chloride channel blocker. R(+)-IAA-94 inhibits Nef-sdAb19 interaction and binds to Nef.

Chemical Information
Molecular Weight 357.23
Formula C17H18Cl2O4
CAS Number 54197-31-8
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wei Zhao, et al. Mol Med Rep. Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway

[2] Wei Zhao, et al. Mol Med Rep. Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway

[3] Silvia Liskova, et al. Biomed Res Int. Contribution of Ca²⁺-dependent Cl⁻ channels to norepinephrine-induced contraction of femoral artery is replaced by increasing EDCF contribution during ageing

[4] Stephen D Skaper, et al. Neurochem Res. Intracellular ion channel CLIC1: involvement in microglia-mediated β-amyloid peptide(1-42) neurotoxicity

[5] N S Pollock, et al. Biophys J. Chloride channel blockers inhibit Ca2+ uptake by the smooth muscle sarcoplasmic reticulum

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Keywords: R(+)-IAA-94, R(+)-Methylindazone supplier, Chloride Channel, inhibitors, activators

 
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