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(R)-MG-132

Cat. No. M13366
(R)-MG-132 Structure
Synonym:

Z-Leu-Leu-Leu-al

Size Price Availability
5mg USD 76  USD76 Out of stock
10mg USD 104  USD104 Out of stock
50mg USD 230  USD230 Out of stock
100mg USD 350  USD350 Out of stock
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Quality Control & Documentation
Biological Activity

(R)-MG-132(Z-LEu-LEu-Al) is a cellular permeable proteasome and Calpain inhibitor with IC50 of 100 nM and 1.2 μM, respectively.

Chemical Information
Molecular Weight 475.62
Formula C26H41N3O5
CAS Number 1211877-36-9
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage -20°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xun Wang, et al. Cell Signal. UBE2D3 contributes to myocardial ischemia-reperfusion injury by regulating autophagy in dependence of p62/SQSTM1

[2] Xinhua Wu, et al. Exp Ther Med. Impact of proteasome inhibitor MG-132 on expression of NF-κB, IL-1β and histological remodeling after myocardial infarction

[3] Juke Ma, et al. Mol Med Rep. MG‑132 reverses multidrug resistance by activating the JNK signaling pathway in FaDu/T cells

[4] Chenming Wu, et al. Cell Death Differ. USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization

[5] Wenhua Bao, et al. Mol Med Rep. Induction of autophagy by the MG‑132 proteasome inhibitor is associated with endoplasmic reticulum stress in MCF‑7 cells

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Keywords: (R)-MG-132, Z-Leu-Leu-Leu-al supplier, Proteasome, inhibitors, activators


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