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(R)-Budesonide

Cat. No. M6281
(R)-Budesonide Structure
Size Price Availability Quantity
5mg USD 300  USD300 In stock
10mg USD 500  USD500 In stock
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Quality Control & Documentation
Biological Activity

Budesonide can attenuate lung injuries induced by chlorine gas, surfactant-depletion, aspiration or LPS in short-term experiments. However, long-term outcome of budesonide applications in endotoxin-induced lung injuries remains unclear. Indeed, long-term application of glucocorticoids to treat ARDS remains controversial.

Protocol (for reference only)
Cell Experiment
Cell lines NSCLC cell lines
Preparation method Antagonists were added 1 h before agonists for the corresponding receptors. Charcoal stripped serum was used in the medium when cells were treated with budesonide.
Concentrations 50 nM
Incubation time 24 h
Animal Experiment
Animal models male New Zealand white rabbits
Formulation saline
Dosages 0.5 mg/kg
Administration i.v.
Chemical Information
Molecular Weight 430.53
Formula C25H34O6
CAS Number 51372-29-3
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wang C, et al. J Allergy Clin Immunol. Effect of budesonide transnasal nebulization in patients with eosinophilic chronic rhinosinusitis with nasal polyps.

[2] Liang H, et al. Mol Carcinog. Differential effects on lung cancer cell proliferation by agonists of glucocorticoid and PPARα receptors.

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