Free shipping on all orders over $ 500

(R)-Baclofen

Cat. No. M2005
(R)-Baclofen Structure
Synonym:

STX 209

Size Price Availability Quantity
100mg USD 240 In stock
50mg USD 240 In stock
200mg USD 300 In stock
1g USD 1080 In stock
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

(R)-baclofen is a racemic GABA(B) receptor agonist that has a number of significant pharmacokinetic limitations, including a narrow window of absorption in the upper small intestine and rapid clearance from the blood. (R)-baclofen is primarily used to treat spasticity. In clinical use, arbaclofen placarbil may improve the treatment of patients with gastroesophageal reflux disease, spasticity, and numerous other conditions by prolonging exposure and decreasing the fluctuations in plasma levels of R-baclofen.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 213.66
Formula C10H12ClNO2
CAS Number 69308-37-8
Purity >99%
Solubility Water
Storage at -20°C
References

Arbaclofen placarbil, a novel R-baclofen prodrug: improved absorption, distribution, metabolism, and elimination properties compared with R-baclofen.
Lal R, et al. J Pharmacol Exp Ther. 2009 Sep;330(3):911-21. PMID: 19502531.

Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations.
Falch E, et al. J Neurochem. 1986 Sep;47(3):898-903. PMID: 3016189.

Related GABA Receptor Products
Zolpidem

Zolpidem is a benzodiazepine agonist with high selectivity for α1-subunit-containing GABAA receptors.

Tiagabine HCl

Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.

Tiagabine

Tiagabine is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.

Piperazine

Piperazine, GABA receptor agonist, is an anthelmintic used in the treatment of the intestinal nematodes Ascaris lumbricoides and Enterobius vermicularis.

Pentylenetetrazol

Pentylenetetrazol displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: (R)-Baclofen, STX 209 supplier, GABA Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.