Prosapogenin A is a natural product from Veratrum, induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis. Prosapogenin A (Polyphyllin E) is one of the important monomers of Chonglou extract, which has good anticancer effect. Prosapogenin A monomer showed a good in vitro antitumor effect on colon cancer cells. Compared with oxaliplatin, a commonly used anti-tumor compound, Prosapogenin A (Polyphyllin E) has strong anti-tumor properties on colon cancer cells and has the potential to become an effective anti-colon cancer compound.
| Molecular Weight | 722.90 |
| Formula | C39H62O12 |
| CAS Number | 19057-67-1 |
| Solubility (25°C) | DMSO ≥ 80 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Apoptosis Products |
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Celosin K, a triterpenoid saponin isolated from the seeds of Semen Celosiae, is also a potent inhibitor of t-BHP-induced neuronal damage. In addition, Celosin K inhibits oxidative stress, apoptosis, and autophagy. |
| GLP-2(rat)
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