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Propyphenazone

Cat. No. M5907
Propyphenazone Structure
Size Price Availability Quantity
50mg USD 120 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 230.31
Formula C14H18N2O
CAS Number 479-92-5
Purity >99%
Solubility 2.6 mg/mL in DMSO
Storage at -20°C
References

Hair analysis to monitor abuse of analgesic combinations containing butalbital and propyphenazone.
Ferrari A, et al. J Pharm Biomed Anal. 2015 Nov 10;115:576-9. PMID: 26319751.

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  Catalog
Abmole Inhibitor Catalog 2017




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