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Propranolol

Cat. No. M11540
Propranolol Structure
Size Price Availability Quantity
100mg USD 165  USD165 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Propranolol is a non-selective β-adrenergic receptor (βAR) antagonist, which has high affinity for β1AR and β2AR with Ki value of 1.8 nM and 0.8 nM, respectively. Propranolol inhibited the binding of [3H]-DHA to rat meninges with an IC50 of 12 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 259.34
Formula C16H21NO2
CAS Number 525-66-6
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] James C Lee, et al. Plast Reconstr Surg. Propranolol Therapy in Infantile Hemangioma: It Is Not Just About the Beta

[2] Stephanie Frost, et al. Pediatr Dermatol. Propranolol's effects on the sleep of infants with hemangiomas: A prospective pilot study

[3] Sonika Batra, et al. Biomed Chromatogr. Methods and approaches for determination and enantioseparation of (RS)-propranolol

[4] Abdulrahman A Al-Majed, et al. Profiles Drug Subst Excip Relat Methodol. Propranolol

[5] No authors listed. Br Med J. Propranolol

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