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Propoxycaine hydrochloride

Cat. No. M14272
Propoxycaine hydrochloride Structure
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Biological Activity

Propoxycaine hydrochloride inhibits voltage-gated sodium channels, and thereby inhibits the ionic flux required for the initiation and conduction of impulses. Propoxycaine hydrochloride application can lead to a loss of sensation.

Chemical Information
Molecular Weight 330.85
Formula C16H27ClN2O3
CAS Number 550-83-4
Solubility (25°C) Water 90 mg/mL
DMSO 50 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Annie M Wu, et al. A Videographic Evaluation of Eyedrop Administration by Ophthalmic Technicians

[2] Zixin Yang, et al. Identification, synthesis and structural confirmation of process-related impurities in proparacaine hydrochloride

[3] M L TAINTER, et al. New local anesthetic solutions containing propoxycaine

[4] E L PRATT. Spectrophotometric titrations with nitrous acid. I. The estimation of procaine hydrochloride, propoxycaine hydrochloride, and tetracaine hydrochloride

[5] Meredith L Storms, et al. Stability-indicating HPLC assays for the determination of prilocaine and procaine drug combinations

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