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Propacetamol Hydrochloride

Cat. No. M6193
Propacetamol Hydrochloride Structure
Size Price Availability Quantity
50mg USD 220 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

These renal pathological analyses showed that propacetamol injection induced AIKI in a subset of mice similar to those observed in APAP overdose patients.

Cell Experiment
Cell lines HEK 293 cells
Preparation method To investigate whether PPCM exhibits hTRPV1-activating properties, HEK 293 cells expressing wild-type hTRPV1 were examined by standard whole-cell voltage clamp experiments. Measuring ramp currents by 500-millisecond depolarizations from −100 to +100 mV, we applied PPCM at increasing concentrations (1 µM to 10 mM).
Concentrations 1 µM to 10 mM
Incubation time 24 h
Animal Experiment
Animal models Male 7-week-old BALB/c mice
Dosages 600mg/kg
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 300.78
Formula C14H20N2O3.HCl
CAS Number 66532-86-3
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C

Propacetamol-Induced Injection Pain Is Associated with Activation of Transient Receptor Potential Vanilloid 1 Channels.
Schillers F, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):18-25. PMID: 27457427.

Galangin Prevents Acute Hepatorenal Toxicity in Novel Propacetamol-Induced Acetaminophen-Overdosed Mice.
Tsai MS, et al. J Med Food. 2015 Nov;18(11):1187-97. PMID: 26501381.

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