Pronase E (Activity ≥ 7000 U/g) is a proteolytic enzyme mixture obtained from Streptomyces griseus that is able to digest proteins into individual amino acids.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
|Body Surface Area (m2)
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by
||Animal B Km
|Animal A Km
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
||DMSO ≥ 40 mg/mL
-20°C , protect from light , dry , sealed