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Promethazine hydrochloride

Cat. No. M3665
Promethazine hydrochloride Structure
Size Price Availability Quantity
500mg USD 50  USD50 In stock
1g USD 60  USD60 In stock
5g USD 85  USD85 In stock
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Quality Control & Documentation
Biological Activity

Promethazine has strong sedative and weak antipsychotic effects. Promethazine reduces motion sickness and has antiemetic and anticholinergic properties. The apparent ability of topical H1r/2r antagonists to target epidermal H1/2r is translated into increased efficacy in the treatment of inflammatory dermatoses, likely due to decreased inflammation and enhanced barrier function.

Chemical Information
Molecular Weight 320.88
Formula C17H21ClN2S
CAS Number 58-33-3
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Cantisani C, et al. Biomed Res Int. Topical promethazine side effects: our experience and review of the literature.

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