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Promethazine hydrochloride

Cat. No. M3665
Promethazine hydrochloride Structure
Size Price Availability Quantity
10mM*1mL In DMSO USD 90 In stock
100mg USD 90 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Promethazine has strong sedative and weak antipsychotic effects. Promethazine reduces motion sickness and has antiemetic and anticholinergic properties. The apparent ability of topical H1r/2r antagonists to target epidermal H1/2r is translated into increased efficacy in the treatment of inflammatory dermatoses, likely due to decreased inflammation and enhanced barrier function.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 320.88
Formula C17H21ClN2S
CAS Number 58-33-3
Purity >98%
Solubility DMSO
Storage at -20°C
References

Topical promethazine side effects: our experience and review of the literature.
Cantisani C, et al. Biomed Res Int. 2013;2013:151509. PMID: 24350243.

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Abmole Inhibitor Catalog 2017




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