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Procyanidin B4

Cat. No. M4987
Procyanidin B4 Structure
Size Price Availability Quantity
5mg USD 980 In stock
10mg USD 1680 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Antiviral [herpes simplex virus (HSV) and human immunodeficiency virus (HIV)], antibacterial, superoxide radical-scavenging, and complement-modulating properties were assessed. In general, more pronounced activities were seen with epicatechin-containing dimers for anti-HSV, anti-HIV, and radical-scavenging effects, while the presence of ortho-trihydroxyl groups in the B-ring was important in compounds exhibiting anti-HSV and radical-scavenging effects and complement classical pathway inhibition.

Customer Product Validations & Biological Datas
Source Can J Physiol Pharmacol (2012). Figure 6. Procyanidin B4
Method AGE formation assay
Cell Lines
Concentrations 50 to 100 mg
Incubation Time
Results No single biomarker could efficiently and significantly predict antiglycation activity.
Cell Experiment
Cell lines RAW 264.7 cells
Preparation method At 80-90% confluency, the medium was replaced with a colorless DMEM medium with antibiotics and without FBS, and then the cells were stimulated with LPS and coincubated with procyanidins and PUFAs with a final concentration for the following compounds: B1, B2, B3, and B4 (5 mg/mL or 8.64 μM), and DHA and EPA (30 μM). After 19 h of treatment, the supernatant was collected and stored at -20℃.
Concentrations 8.64 μM
Incubation time 19 h
Animal Experiment
Animal models male castrated pigs
Formulation water
Dosages 10 mg/kg
Administration oral
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 578.52
Formula C30H26O12
CAS Number 29106-51-2
Purity >98%
Solubility DMSO
Storage at -20°C

Systemic absorption and metabolism of dietary procyanidin B4 in pigs.
Bittner K, et al. Mol Nutr Food Res. 2014 Dec;58(12):2261-73. PMID: 25263999.

Biological evaluation of proanthocyanidin dimers and related polyphenols.
De Bruyne T, J Nat Prod 1999 Jul;954-8. PMID: 10425115.

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