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Procaine

Cat. No. M5899
Procaine Structure
Synonym:

Procaine, Novocaine, Vitamin H3, Duracaine, Spinocaine

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
50mg USD 60 In stock
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Quality Control
Biological Activity

Procaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 236.31
Formula C13H20N2O2
CAS Number 59-46-1
Purity >99%
Solubility 47 mg/mL in DMSO
Storage at -20°C
References

Intramuscular administration of sodium benzylpenicillin in horses as an alternative to procaine benzylpenicillin.
Olsén L, et al. Res Vet Sci. 2013 Aug;95(1):212-8. PMID: 23419937.

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Keywords: Procaine, Procaine, Novocaine, Vitamin H3, Duracaine, Spinocaine supplier, Sodium Channel, inhibitors

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